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The Impact of Low Flow Nocturnal Oxygen Therapy on Hospital Admissions and Mortality in Patients with Heart Failure and Central Sleep Apnea

About the Trial

The Impact of Low Flow Nocturnal Oxygen Therapy on Hospital Admissions and Mortality in Patients with Heart Failure and Central Sleep Apnea (LOFTHF) study is a research study for patients with heart failure and a specific type of sleep apnea, central sleep apnea (CSA). This project is designed to find out whether nighttime oxygen therapy improves heart failure and well-being in patients with heart failure and CSA.

Participate

Why you may choose to participate:

Many people with heart failure also have central sleep apnea (CSA). Sleep apnea is a disorder where breathing pauses occur during sleep. Sleep apnea can cause poor sleep quality and worsen heart function. However, there are no documented effective treatments for patients with heart failure and CSA. Nighttime use of supplemental oxygen may improve heart failure and general health, but has not been rigorously studied. The LOFT-HF study is designed to help us understand how to better treat patients with heart failure who have sleep apnea.

During this study you will:

  • Learn more about sleep disorders and treatments for CSA
  • Help doctors learn more about CSA in patients with heart failure
Who may participate:
  • Adults over 21 years of age who have been diagnosed with heart failure
What is involved (randomization):

Participants will be assessed for CSA based on a prior sleep study or an at-home sleep study completed during study participation. Individuals will then be randomly placed into one of two groups:

  • Using enriched oxygen during sleep at night
  • Using room-air level oxygen during sleep at night
All participants will receive:
  • Information about sleep habits and how to use the study equipment
  • Up to 4 daytime study visits (can be done by phone), which will include:
    • Gathering of information about your medical history
    • Participant questionnaires
    • Instruction on use of study equipment
  • Periodic phone calls to review:
    • Any changes in medications
    • Any changes in health
    • Experience using study treatment
Please keep in mind:
  • Participation is voluntary.
  • You are free to withdraw from this study at any time.
  • We encourage you to ask questions, and express all of your concerns.
  • Your health is important to us.
  • We will reimburse you for your time

Contact Us

our address
Brigham Health
Division of Sleep and Circadian Disorders
221 Longwood Avenue, BLI 225
Boston, MA 02115